422 research outputs found
A runaway collision in a young star cluster as the origin of the brightest supernova
Supernova 2006gy in the galaxy NGC 1260 is the most luminous one recorded
\cite{2006CBET..644....1Q, 2006CBET..647....1H, 2006CBET..648....1P,
2006CBET..695....1F}. Its progenitor might have been a very massive (
\msun) star \cite{2006astro.ph.12617S}, but that is incompatible with hydrogen
in the spectrum of the supernova, because stars \msun are believed to
have shed their hydrogen envelopes several hundred thousand years before the
explosion \cite{2005A&A...429..581M}. Alternatively, the progenitor might have
arisen from the merger of two massive stars \cite{2007ApJ...659L..13O}. Here we
show that the collision frequency of massive stars in a dense and young cluster
(of the kind to be expected near the center of a galaxy) is sufficient to
provide a reasonable chance that SN 2006gy resulted from such a bombardment. If
this is the correct explanation, then we predict that when the supernova fades
(in a year or so) a dense cluster of massive stars becomes visible at the site
of the explosion
Early diastolic filling dynamics in diastolic dysfunction
BACKGROUND: The aim of the study was to determine the relationship between the rate of peak early mitral inflow velocity and the peak early diastolic mitral annular tissue velocities in normal controls and to compare them with subjects with diastolic dysfunction. METHODS: The relationship between early passive diastolic transmitral flow and peak early mitral annular velocity in the normal and in diastolic dysfunction was studied. Two groups comprising 22 normal controls and 25 patients with diastolic dysfunction were studied. RESULTS: Compared with the normal group, those with diastolic dysfunction had a lower E/A ratio (0.7 ± 0.2 vs. 1.9 ± 0.5, p < 0.001), a higher time-velocity integral of the atrial component (11.7 ± 3.2 cm vs. 5.5 ± 2.1 cm, p < 0.0001), a longer isovolumic relaxation time 73 ± 12 ms vs. 94 ± 6 ms, p < 0.01 and a lower rate of acceleration of blood across the mitral valve (549.2 ± 151.9 cm/sec(2 )vs. 871 ± 128.1 cm/sec(2), p < 0.001). They also had a lower mitral annular relaxation velocity (Ea) (6.08 ± 1.6 cm/sec vs 12.8 ± 0.67 cm/sec, p < 0.001), which was positively correlated to the acceleration of early diastolic filling (R = 0.66), p < 0.05. CONCLUSIONS: This investigation provides information on the acceleration of early diastolic filling and its relationship to mitral annular peak tissue velocity (Ea) recorded by Doppler tissue imaging. It supports not only the premise that recoil is an important mechanism for rapid early diastolic filling but also the existence of an early diastolic mechanism in normal
Physical and mental health comorbidity is common in people with multiple sclerosis: nationally representative cross-sectional population database analysis
<b>Background</b> Comorbidity in Multiple Sclerosis (MS) is associated with worse health and higher mortality. This study aims to describe clinician recorded comorbidities in people with MS. <p></p>
<b>Methods</b> 39 comorbidities in 3826 people with MS aged ≥25 years were compared against 1,268,859 controls. Results were analysed by age, gender, and socioeconomic status, with unadjusted and adjusted Odds Ratios (ORs) calculated using logistic regression. <p></p>
<b>Results</b> People with MS were more likely to have one (OR 2.44; 95% CI 2.26-2.64), two (OR 1.49; 95% CI 1.38-1.62), three (OR 1.86; 95% CI 1.69-2.04), four or more (OR 1.61; 95% CI 1.47-1.77) non-MS chronic conditions than controls, and greater mental health comorbidity (OR 2.94; 95% CI 2.75-3.14), which increased as the number of physical comorbidities rose. Cardiovascular conditions, including atrial fibrillation (OR 0.49; 95% CI 0.36-0.67), chronic kidney disease (OR 0.51; 95% CI 0.40-0.65), heart failure (OR 0.62; 95% CI 0.45-0.85), coronary heart disease (OR 0.64; 95% CI 0.52-0.71), and hypertension (OR 0.65; 95% CI 0.59-0.72) were significantly less common in people with MS. <p></p>
<b>Conclusion</b> People with MS have excess multiple chronic conditions, with associated increased mental health comorbidity. The low recorded cardiovascular comorbidity warrants further investigation
Characterizing the non-linear growth of large-scale structure in the Universe
The local Universe displays a rich hierarchical pattern of galaxy clusters
and superclusters. The early Universe, however, was almost smooth, with only
slight 'ripples' seen in the cosmic microwave background radiation. Models of
the evolution of structure link these observations through the effect of
gravity, because the small initially overdense fluctuations attract additional
mass as the Universe expands. During the early stages, the ripples evolve
independently, like linear waves on the surface of deep water. As the
structures grow in mass, they interact with other in non-linear ways, more like
waves breaking in shallow water. We have recently shown how cosmic structure
can be characterized by phase correlations associated with these non-linear
interactions, but hitherto there was no way to use that information to reach
quantitative insights into the growth of structures. Here we report a method of
revealing phase information, and quantify how this relates to the formation of
a filaments, sheets and clusters of galaxies by non-linear collapse. We use a
new statistic based on information entropy to separate linear from non-linear
effects and thereby are able to disentangle those aspects of galaxy clustering
that arise from initial conditions (the ripples) from the subsequent dynamical
evolution.Comment: Accepted for publication in Nature. For high-resolution Figure 3,
please see http://www.nottingham.ac.uk/~ppzpc/phases/n0colorphase.html, For
the animations and the idea of this paper please see
http://www.nottingham.ac.uk/~ppzpc/phases/index.htm
A Blast Wave from the 1843 Eruption of Eta Carinae
Very massive stars shed much of their mass in violent precursor eruptions as
luminous blue variables (LBVs) before reaching their most likely end as
supernovae, but the cause of LBV eruptions is unknown. The 19th century
eruption of Eta Carinae, the prototype of these events, ejected about 12 solar
masses at speeds of 650 km/s, with a kinetic energy of almost 10^50 ergs. Some
faster material with speeds up to 1000-2000 km/s had previously been reported
but its full distribution was unknown. Here I report observations of much
faster material with speeds up to 3500-6000 km/s, reaching farther from the
star than the fastest material in earlier reports. This fast material roughly
doubles the kinetic energy of the 19th century event, and suggests that it
released a blast wave now propagating ahead of the massive ejecta. Thus, Eta
Car's outer shell now mimics a low-energy supernova remnant. The eruption has
usually been discussed in terms of an extreme wind driven by the star's
luminosity, but fast material reported here suggests that it was powered by a
deep-seated explosion rivalling a supernova, perhaps triggered by the
pulsational pair instability. This may alter interpretations of similar events
seen in other galaxies.Comment: 10 pages, 3 color figs, supplementary information. Accepted by Natur
ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms
<p>Abstract</p> <p>Background</p> <p>Zinc Finger Nucleases (ZFNs) have tremendous potential as tools to facilitate genomic modifications, such as precise gene knockouts or gene replacements by homologous recombination. ZFNs can be used to advance both basic research and clinical applications, including gene therapy. Recently, the ability to engineer ZFNs that target any desired genomic DNA sequence with high fidelity has improved significantly with the introduction of rapid, robust, and publicly available techniques for ZFN design such as the Oligomerized Pool ENgineering (OPEN) method. The motivation for this study is to make resources for genome modifications using OPEN-generated ZFNs more accessible to researchers by creating a user-friendly interface that identifies and provides quality scores for all potential ZFN target sites in the complete genomes of several model organisms.</p> <p>Description</p> <p>ZFNGenome is a GBrowse-based tool for identifying and visualizing potential target sites for OPEN-generated ZFNs. ZFNGenome currently includes a total of more than 11.6 million potential ZFN target sites, mapped within the fully sequenced genomes of seven model organisms; <it>S. cerevisiae, C. reinhardtii, A. thaliana</it>, <it>D. melanogaster, D. rerio, C. elegans</it>, and <it>H. sapiens </it>and can be visualized within the flexible GBrowse environment. Additional model organisms will be included in future updates. ZFNGenome provides information about each potential ZFN target site, including its chromosomal location and position relative to transcription initiation site(s). Users can query ZFNGenome using several different criteria (e.g., gene ID, transcript ID, target site sequence). Tracks in ZFNGenome also provide "uniqueness" and ZiFOpT (Zinc Finger OPEN Targeter) "confidence" scores that estimate the likelihood that a chosen ZFN target site will function <it>in vivo</it>. ZFNGenome is dynamically linked to ZiFDB, allowing users access to all available information about zinc finger reagents, such as the effectiveness of a given ZFN in creating double-stranded breaks.</p> <p>Conclusions</p> <p>ZFNGenome provides a user-friendly interface that allows researchers to access resources and information regarding genomic target sites for engineered ZFNs in seven model organisms. This genome-wide database of potential ZFN target sites should greatly facilitate the utilization of ZFNs in both basic and clinical research.</p> <p>ZFNGenome is freely available at: <url>http://bindr.gdcb.iastate.edu/ZFNGenome</url> or at the Zinc Finger Consortium website: <url>http://www.zincfingers.org/</url>.</p
Development of genomic resources for the narrow-leafed lupin (Lupinus angustifolius): construction of a bacterial artificial chromosome (BAC) library and BAC-end sequencing
Extent: 15p.BACKGROUND: Lupinus angustifolius L, also known as narrow-leafed lupin (NLL), is becoming an important grain legume crop that is valuable for sustainable farming and is becoming recognised as a potential human health food. Recent interest is being directed at NLL to improve grain production, disease and pest management and health benefits of the grain. However, studies have been hindered by a lack of extensive genomic resources for the species. RESULTS: A NLL BAC library was constructed consisting of 111,360 clones with an average insert size of 99.7 Kbp from cv Tanjil. The library has approximately 12 × genome coverage. Both ends of 9600 randomly selected BAC clones were sequenced to generate 13985 BAC end-sequences (BESs), covering approximately 1% of the NLL genome. These BESs permitted a preliminary characterisation of the NLL genome such as organisation and composition, with the BESs having approximately 39% G:C content, 16.6% repetitive DNA and 5.4% putative gene-encoding regions. From the BESs 9966 simple sequence repeat (SSR) motifs were identified and some of these are shown to be potential markers. CONCLUSIONS: The NLL BAC library and BAC-end sequences are powerful resources for genetic and genomic research on lupin. These resources will provide a robust platform for future high-resolution mapping, map-based cloning, comparative genomics and assembly of whole-genome sequencing data for the species.Ling-Ling Gao, James K. Hane, Lars G. Kamphuis, Rhonda Foley, Bu-Jun Shi, Craig A. Atkins and Karam B. Sing
The Evolution of Compact Binary Star Systems
We review the formation and evolution of compact binary stars consisting of
white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and
BHs are thought to be the primary astrophysical sources of gravitational waves
(GWs) within the frequency band of ground-based detectors, while compact
binaries of WDs are important sources of GWs at lower frequencies to be covered
by space interferometers (LISA). Major uncertainties in the current
understanding of properties of NSs and BHs most relevant to the GW studies are
discussed, including the treatment of the natal kicks which compact stellar
remnants acquire during the core collapse of massive stars and the common
envelope phase of binary evolution. We discuss the coalescence rates of binary
NSs and BHs and prospects for their detections, the formation and evolution of
binary WDs and their observational manifestations. Special attention is given
to AM CVn-stars -- compact binaries in which the Roche lobe is filled by
another WD or a low-mass partially degenerate helium-star, as these stars are
thought to be the best LISA verification binary GW sources.Comment: 105 pages, 18 figure
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